Effects of supplementing different chromium histidinate complexes on glucose and lipid metabolism and related protein expressions in rats fed a high-fat diet |
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| Institution: | 1. Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey;2. Department of Animal Nutrition and Nutritional Diseases, School of Veterinary Medicine, Erciyes University, Kayseri, Turkey;3. Department of Biology, Faculty of Science, Firat University, Elazig, Turkey;4. Research and Development, Nutrition 21, LLC, NY, United States;1. Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey;2. Department of Animal Nutrition and Nutritional Diseases, School of Veterinary Medicine, Erciyes University, Kayseri, Turkey;3. Department of Biology, Faculty of Science, Firat University, Elazig, Turkey;4. Research and Development, Nutrition 21, LLC, NY, United States;1. Department of Chemistry, College of Science, University of Kufa, Iraq;2. Clinical Analysis Department, College of Pharmacy, Hawler Medical University, Havalan City, Erbil, Iraq;3. Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;4. Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria;5. IMPACT Strategic Research Centre, Deakin University, PO Box 281, Geelong, VIC, 3220, Australia;1. Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131, Ancona, Italy;2. School of Pharmacy, University of Camerino, Camerino, MC, Italy;3. School of Pharmacy and Health Products, University of Camerino, 62032, Camerino, Italy;1. Department of Chemistry, Faculty of Science, University of Kerbala, Karbala, Iraq;2. ICP-MS Facility, Department of Chemistry, Faculty of Engineering and Physical Sciences, Guildford, Surrey, GU2 7XH, UK;1. Programa de Pós-graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, CEP 96010-900, RS, Brazil;2. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark;3. Seleno Therapeutics Pty. Ltd., Brighton East, VIC, 3187, Australia;4. Laboratório de Genômica Estrutural, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, CEP 96010-900, RS, Brazil;5. Laboratório Regional de Diagnóstico Faculdade de Veterinária, Universidade Federal de Pelotas, Pelotas, CEP 96010-900, RS, Brazil;1. Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Patología, Av. San Martín 5285, C1427CWO, Ciudad Autónoma de Buenos Aires, Argentina;2. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisicoquímica, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Bioquímica y Medicina Molecular (IBIMOL, UBA-CONICET), Junín 956, C1113AAD, Ciudad Autónoma de Buenos Aires, Argentina;1. Department of Pharmacy, The 967th hospital of People''s Liberation Army, No.80, Shengli Road, Xigang, Dalian, Liaoning, 116021, China;2. Institute of Rare Diseases, West China Hospital, Sichuan University, No.37, Guoxue Alley, Wuhou, Chengdu, Sichuan, 610041, China |
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| Abstract: | BackgroundThe objective of this study was to investigate the effects of different chromium histidinate (CrHis) complexes added to the diet of rats fed a high-fat diet (HFD) on body weight changes, glucose and lipid metabolism parameters, and changes in biomarkers such as PPAR-γ, IRS-1, GLUTs, and NF-κB proteins.MethodsForty-two Sprague–Dawley rats were divided equally into six groups and fed either a control, an HFD, or an HFD supplemented with either CrHis1, CrHis2, CrHis3, or a combination of the CrHis complexes as CrHisM.ResultsFeeding an HFD to rats increased body weights, HOMA-IR values, fasting serum glucose, insulin, leptin, free fatty acid, total cholesterol, low-density lipoprotein cholesterol, and MDA concentrations as well as AST activities, and decreased serum and brain serotonin concentrations compared with rats fed a control diet (P < 0.0001). The levels of the PPAR-γ, IRS-1, and GLUTs in the liver and brain decreased, while NF-κB level increased, with feeding an HFD (P < 0.05). Although all the CrHis supplements reversed the negative effects of feeding an HFD (P < 0.05), the CrHis1 complex was most effective in changing the protein levels, while CrHisM was most effective in influencing certain parameters such as body weight and serum metabolites.ConclusionThe results of the present work suggest that the CrHis1 complex is most potent for alleviating the negative effects of feeding an HFD. The efficacy of CrHisM is likely due to the presence of the CrHis1 complex. |
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| Keywords: | Chromium histidinate High-fat diet Insulin Lipids Biomarkers Rats |
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