Prenatal and postnatal exposure to vanadium and the immune function of children |
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| Affiliation: | 1. Division of Nephrology, Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, 300, Taiwan;2. Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, 300, Taiwan;3. Department of Emergency Medicine, En Chu Kong Hospital, New Taipei City, 237, Taiwan;4. Department of Environmental Engineering and Health, Yuanpei University of Medical Technology, Hsinchu, 300, Taiwan;5. Department of Internal Medicine, En Chu Kong Hospital, New Taipei City, 237, Taiwan;6. Department of Nursing, Yuanpei University of Medical Technology, Hsinchu, 300, Taiwan;7. School of Medicine, Fu Jen Catholic University, New Taipei City, 242, Taiwan;1. Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China;2. Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, Guangxi, China;3. Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China;4. Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin, 541100, Guangxi, China;1. Chair and Department of Human Anatomy, Medical University of Lublin, 20-090, Lublin, Poland;2. Department of Biochemistry and Toxicology, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, 20-950, Lublin, Poland;3. Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Department of Biological Function of Food, Tuwima 10, 10-748, Olsztyn, Poland;1. Virginia Commonwealth University School of Medicine, Division of Hospital Medicine, Department of Internal Medicine, Richmond, VA, 23298, United States;2. Eastern Virginia Medical School, Department of Internal Medicine, Norfolk, VA, 23507, United States;2. School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271016, China;1. Laboratoire de pharmacologie-toxicologie, CHU Angers, France;2. Groupe d''Étude des Interactions Hôte-Pathogène (GEIHP) EA 3142, Université d''Angers-Université de Brest, Angers, France;3. Service de réanimation chirurgicale, CHU Tours, France;4. Cabinet de dermatologie, Porto Vecchio, France;5. Service de réanimation des brûlés, CHU Tours, France;6. Laboratoire de pharmacologie-toxicologie, CHU Reims, France;7. Centre médical, Porto Vecchio, France;8. Laboratoire de pharmacologie-toxicologie, CHU Tours, France;9. Centre anti-poison-toxicovigilance, CHU Angers, France |
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| Abstract: | BackgroundThe immunotoxicity induced by vanadium exposure have been reported in some toxicology researches. However, evidence from population-based epidemiological studies was lacking.MethodsThis study was conducted to assess the associations between prenatal and postnatal exposure to vanadium and immune function of children. A total of 407 pre-school aged children were followed, whose peripheral blood was collected for T lymphocyte subsets and inflammatory cytokines analysis, as well as vanadium concentration measurement. Maternal urine samples were also collected to measure vanadium concentration. We used generalized linear models to evaluate the associations of maternal and children vanadium concentration with children’s immune function. Stratification analysis was further conducted to explore the potential gender-specific effects.ResultsThe geometric means of vanadium concentration in maternal urine and children plasma were 0.85 and 1.12 μg/L, respectively. Maternal urinary vanadium was inversely associated with the percentage of CD3+CD4+ cells [-5.53 % (-10.38 %, -0.41 %)] and absolute counts of CD3+ cells [-2.43 % (-5.05 %, 0.25 %)], and we only observed significant negative associations in males when stratifying by fetal gender. Children plasma vanadium was also associated with reduced absolute counts of CD3+ cells [-5.25 % (-9.57 %, -0.73 %)], but gender-specific effects were not observed. No significant associations of vanadium exposure with cytokines were found.ConclusionsPrenatal and postnatal exposure to vanadium had suppressive impacts on childhood cellular immune. Further studies are needed to confirm our findings. |
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| Keywords: | Vanadium Prenatal exposure Postnatal exposure T lymphocytes Cytokines |
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