Membrane proteins enter the fold |
| |
Institution: | 1. Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden;2. Science for Life Laboratory, Stockholm University, Box 1031, SE-171 21 Solna, Sweden;3. Department of Physiology and Biophysics and the Center for Biomembrane Systems, University of California, Irvine, CA 92697, USA |
| |
Abstract: | Membrane proteins have historically been recalcitrant to biophysical folding studies. However, recent adaptations of methods from the soluble protein folding field have found success in their applications to transmembrane proteins composed of both α-helical and β-barrel conformations. Avoiding aggregation is critical for the success of these experiments. Altogether these studies are leading to discoveries of folding trajectories, foundational stabilizing forces and better-defined endpoints that enable more accurate interpretation of thermodynamic data. Increased information on membrane protein folding in the cell shows that the emerging biophysical principles are largely recapitulated even in the complex biological environment. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|