Arsenic and weight loss: At a crossroad between lipogenesis and lipolysis |
| |
| Affiliation: | 1. Medical Biomaterial Research Center (MBRC), Tehran University of Medical Sciences, Tehran, Iran;2. Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;1. Department of Physiology, UCSTA, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India;2. Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, India;1. Physics Department, NOVA School of Science and Technology, NOVA University Lisbon, 2829-516, Caparica, Portugal;2. LIBPhys - Laboratory for Instrumentation, Biomedical Engineering and Radiation Physics, Portugal;3. Anatomy Department, NOVA Medical School, NOVA University Lisbon, 1169-056, Lisbon, Portugal;1. Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, C. Sant Joan s/n, 43201, Reus, Spain;2. Department of Radiation Oncology, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Av. Doctor Josep Laporte 2, 43204, Reus, Spain;1. Department of Public Health, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic;2. Department of Respiratory Diseases, University Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavská 20, 625 00, Brno, Czech Republic;3. Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic;4. Institute of Analytical Chemistry of the Czech Academy of Sciences, Veveří 97, 602 00, Brno, Czech Republic;5. Institute of Laboratory Research on Geomaterials, Faculty of Natural Sciences, Comenius University in Bratislava, Slovakia;1. Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Zografos, Panepistimiopolis, Athens, 15784, Greece;2. Laboratory of Environmental Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Zografos, Panepistimiopolis, Athens, 15784, Greece;3. General Hospital “LAIKO”, Athens, 11527, Greece |
| |
| Abstract: | Arsenic is found in soil, food, water and earth crust. Arsenic exposure is associated with chronic diseases such as cancer, cardiovascular disease as well as diabetes. One of complex effects of arsenic is on weight gain or loss. Involvement of arsenic in both weight loss and gain signaling pathways has previously been reported; however, too little attention has been paid to its weight reducing effect. Animal studies exhibited a role of arsenic in weight loss. In this regard, arsenic interference with endocrine system, leptin and adiponectin hormones as well as thermogenesis is more evidence. Apparently, arsenic-induced weight lossis generally meditated by its interaction with thermogenesis. In this review we have discussed the irregularities in metabolic pathways induced by arsenic that can lead to weight loss. |
| |
| Keywords: | Arsenic Obesity Lipolysis Thermogenesis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
