Renal adaptive response to exposure to low doses of uranyl nitrate and sodium fluoride in mice |
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| Affiliation: | 1. Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-SANTE, SESANE, 92262, Fontenay-aux-Roses, France;2. Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Departamento de Toxicología (CINVESTAV-IPN), Av. IPN No. 2508 Col., San Pedro Zacatenco, México City, CP 07360, Mexico;1. Department of Occupational Health, School of Public Health, Shanxi Medical University, China;2. Key Lab of Environmental Hazard and Health of Shanxi Province, Shanxi Medical University, China;3. Key Lab of Cellular Physiology of Education Ministry, Shanxi Medical University, China;4. Department of Occupational Health, School of Public Health, Jining Medical University, China;5. Department of Pathology, University of Mississippi Medical Center, Jackson, MS, 39216, USA;1. Department of Physiology, Faculty of Pharmacy, Seville University, 41012, Seville, Spain;2. Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal;1. Key Laboratory of Endemic and Ethnic Diseases (Guizhou Medical University), Ministry of Education, PR China;2. Key Laboratory of Medical Molecular Biology (Guizhou Medical University), Guiyang 550004, PR China;3. Department of Pathology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, PR China;1. Bruker-IOCh International Analytical Laboratory Ltd., LLC United Research and Development Centre, 119991 Moscow, Russian Federation;2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation;3. Department of Bioenergetics, Institute of Biology, University of Stuttgart, D-70550 Germany;4. Biolitec Research GmbH, 07745 Jena, Germany;5. Centre de Recherche en Automatique de Nancy (CRAN), UMR 7039, Campus Sciences, Université de Lorraine, 54506 Vandoeuvre-lès-Nancy Cedex, France;1. Laboratoire de RadioToxicologie Expérimentale, Service de Radiobiologie et d’Epidémiologie, Institut de Radioprotection et Sûreté Nucléaire, B.P. 17, 92262 Fontenay aux Roses Cedex, France;2. Department of Environmental Toxicology, Uppsala University, Norbyvägen 18 A, 752 36 Uppsala, Sweden |
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| Abstract: | BackgroundDespite their differences in physicochemical properties, both uranium (U) and fluoride (F) are nephrotoxicants at high doses but their adverse effects at low doses are still the subject of debate. METHODS: This study aims to improve the knowledge of the biological mechanisms involved through an adaptive response model of C57BL/6 J mice chronically exposed to low priming doses of U (0, 10, 20 and 40 mg/L) or F (0, 15, 30 and 50 mg/L) and then challenged with acute exposure of 5 mg/kg U or 7.5 mg/kg NaF.ResultsWe showed that an adaptive response occurred with priming exposures to 20 mg/L U and 50 mg/L F, with decreased levels of the biomarkers KIM-1 and CLU compared to those in animals that received the challenge dose only (positive control). The adaptive mechanisms involved a decrease in caspase 3/7 activities in animals exposed to 20 mg/L U and a decrease in in situ VCAM expression in mice exposed to 50 mg/L F. However, autophagy and the UPR were induced independently of priming exposure to U or F and could not be identified as adaptive mechanisms to U or F.ConclusionTaken together, these results allow us to identify renal adaptive responses to U and F at doses of 20 and 50 mg/L, probably through decrease apoptosis and inflammatory cell recruitment. |
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| Keywords: | Uranyl Fluoride Kidney Adaptation Apoptosis Inflammation |
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