Mechanobiology in cortical waves and oscillations |
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| Affiliation: | 1. Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8002, USA.;2. Department of Cell Biology, School of Medicine, Johns Hopkins University, 855 N Wolfe Street, Baltimore, MD, 21025, USA;1. The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK;2. Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King''s College London, London, SE1 1UL, UK;1. Department of Bioengineering, University of California, Berkeley, CA, 94720, USA;2. Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, 94720, USA;3. UC Berkeley-UCSF Graduate Program in Bioengineering, USA;1. Department of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA;2. Department of Biological Chemistry, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA;1. Department of Cell and Developmental Biology, University of Michigan, USA;2. Department of Cell and Developmental Biology, Vanderbilt University, USA;3. Department of Biomolecular and Chemical Engineering, Department of Biochemistry, Vanderbilt University, USA;1. Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8002, USA;2. Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115, USA |
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| Abstract: | Cortical actin waves have emerged as a widely prevalent phenomena and brought pattern formation to many fields of cell biology. Cortical excitabilities, reminiscent of the electric excitability in neurons, are likely fundamental property of the cell cortex. Although they have been mostly considered to be biochemical in nature, accumulating evidence support the role of mechanics in the pattern formation process. Both pattern formation and mechanobiology approach biological phenomena at the collective level, either by looking at the mesoscale dynamical behavior of molecular networks or by using collective physical properties to characterize biological systems. As such they are very different from the traditional reductionist, bottom-up view of biology, which brings new challenges and potential opportunities. In this essay, we aim to provide our perspectives on what the proposed mechanochemical feedbacks are and open questions regarding their role in cortical excitable and oscillatory dynamics. |
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