Emerging role of selenium in treatment of rheumatoid arthritis: An insight on its antioxidant properties |
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| Affiliation: | 1. Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131, Ancona, Italy;2. School of Pharmacy, University of Camerino, Camerino, MC, Italy;3. School of Pharmacy and Health Products, University of Camerino, 62032, Camerino, Italy;1. Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil;2. Laboratory of Cell Culture and Cytogenetics, Environment Section, Evandro Chagas Institute, Ananindeua, PA, Brazil;3. School of Dentistry, Federal University of Pará, Belém, PA, Brazil;4. Laboratory of Toxicology, Environment Section, Evandro Chagas Institute, Ananindeua, PA, Brazil;5. Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil;1. Department of Materials Engineering, Bu-Ali Sina University, Hamedan, 65178-38695, Iran;2. Environmental Science and Engineering Program, University of Texas at El Paso, El Paso, TX, 79968, USA;1. Department of Clinical Psychology, Poznan University of Medical Sciences, Poland;2. Department of Dietetics, Poznan University of Physical Education, Poland;1. Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland;2. Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany |
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| Abstract: | Rheumatoid Arthritis is an inflammatory disease primarily involves the inflamed synovium, affecting about 0.5–1 % population worldwide. It is the assumption from many years that oxidative stress is involved in the pathophysiology of inflammatory disorders like RA and many others. The significance of micronutrients in arthritis is linked to their role as a cofactor for the activation of selenoenzymes. Dietary interventions can manage the clinical symptoms of RA like pain, swelling and tenderness of joints and their associated disability along the progression of disease. This review highlights the antioxidant potential of selenium in treatment of RA along with the scientific evidence that Se supplementation can reduce disease progression by managing its clinical symptoms. |
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| Keywords: | Selenium Oxidative stress Inflammation Rheumatoid arthritis |
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