Suppressive effect of 1,4-anhydro-4-seleno-D-talitol (SeTal) on atopic dermatitis-like skin lesions in mice through regulation of inflammatory mediators |
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| Affiliation: | 1. Programa de Pós-graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, CEP 96010-900, RS, Brazil;2. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark;3. Seleno Therapeutics Pty. Ltd., Brighton East, VIC, 3187, Australia;4. Laboratório de Genômica Estrutural, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, CEP 96010-900, RS, Brazil;5. Laboratório Regional de Diagnóstico Faculdade de Veterinária, Universidade Federal de Pelotas, Pelotas, CEP 96010-900, RS, Brazil;1. Departamento de Procesos y Tecnología, Universidad Autónoma Metropolitana Unidad Cuajimalpa, Mexico City, Mexico;2. Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, (CINVESTAV-IPN), Mexico City, Mexico;3. Departamento de Microscopía Electrónica, Instituto Mexicano del Petróleo, Mexico City, Mexico;4. BGR Bundesansalt fur Geowissenschaften und Rohstoffe, Stilleweg 2, D-30655, Hannover, Germany;1. Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131, Ancona, Italy;2. School of Pharmacy, University of Camerino, Camerino, MC, Italy;3. School of Pharmacy and Health Products, University of Camerino, 62032, Camerino, Italy;1. Department of Clinical Psychology, Poznan University of Medical Sciences, Poland;2. Department of Dietetics, Poznan University of Physical Education, Poland;1. Department of Pharmacy, The 967th hospital of People''s Liberation Army, No.80, Shengli Road, Xigang, Dalian, Liaoning, 116021, China;2. Institute of Rare Diseases, West China Hospital, Sichuan University, No.37, Guoxue Alley, Wuhou, Chengdu, Sichuan, 610041, China;1. Selcuk University, Faculty of Dentistry, Department of Periodontology, Konya, 42079, Turkey;2. Selcuk University, Research Center of Faculty of Dentistry, Konya, Turkey;3. Bonn University, Medical Faculty, Department of Orthodontics, Oral Biology Lab, Bonn, Germany;4. Bolu Abant İzzet Baysal University, Faculty of Medicine, Department of Biostatistics and Medical İnformatics, Bolu, Turkey;5. Private Practice, Sancakdent Oral Health Center, Istanbul, Turkey;6. Selcuk University, Faculty of Agriculture, Soil Science and Plant Nutrition, Konya, Turkey;7. Selcuk University, Faculty of Veterinary Medicine, Department of Internal Medicine, Konya, Turkey;8. Grand Forks, ND, USA |
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| Abstract: | BackgroundAtopic dermatitis (AD) is a multifactorial chronic inflammatory disease that affects ∼20 % of children and 3% of adults globally and is generally treated by the topical application of steroidal drugs that have undesirable side-effects. The development of alternative therapies is therefore an important objective. The present study investigated the effects of topical treatment with a novel water-soluble selenium-containing carbohydrate derivative (4-anhydro-4-seleno-D-tatitol, SeTal) on the symptoms and inflammatory parameters in an AD mouse model.MethodsMice were sensitized by applying 2,4-dinitrochlorobenzene (DNCB) to their dorsal skin on days 1–3, then further challenged on their ears and dorsal skin on days 14, 17, 20, 23, 26, and 29. SeTal (1 and 2%) or hydrocortisone (1%) was applied topically to the backs of the mice from days 14–29, and skin severity scores and scratching behavior determined on day 30. The mice were euthanized, and their ears and dorsal skin removed to quantify inflammatory parameters, edema, myeloperoxidase (MPO) activity, and AD-associated cytokines (tumor necrosis factor alpha (TNF-α), interleukins (IL)-18, and IL-33).ResultsDNCB treatment induced skin lesions and increased the scratching behavior, ear edema, MPO activity (ear and dorsal skin), and cytokine levels in dorsal skin. Topical application of SeTal improved inflammatory markers (cytokine levels and MPO activity), cutaneous severity scores, and scratching behavior.ConclusionThe efficacy of SeTal was satisfactory in the analyzed parameters, showing similar or better results than hydrocortisone. SeTal appears to be therapeutically advantageous for the treatment and control of AD. |
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| Keywords: | Cytokine Selenium 4-Anhydro-4-seleno-D-talitol Inflammation Hydrocortisone |
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