Human biomonitoring of 73 elements in blood,serum, erythrocytes and urine |
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| Affiliation: | 1. University of Belgrade – Faculty of Chemistry, Studentski trg 16, 11000 Belgrade, Serbia;2. Department of Physiology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Bulevar despota Stefana 142, Belgrade 11060, Serbia;3. Faculty of Medicine, University of Belgrade, Dr Subotića 8, 11000 Belgrade, Serbia;4. Clinical Center of Serbia, Neurosurgery Division, Dr Koste Torodorića 4, 11000 Belgrade, Serbia;5. South Ural State University, Lenin prospect 76, 454080 Chelyabinsk, Russia;1. Department of Global Environmental Health Sciences, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA;2. Department of Public Administration, North Carolina Central University, 1801 Fayetteville St, Durham, NC, 27707, USA;3. Sanford School of Public Policy, Duke University, Box 90239, Durham, NC, 27708, USA;4. Institute of Water Policy, Lee Kwan Yew School of Public Policy, National University of Singapore, Singapore;5. Addis Ababa University, Faculty of Medicine, Addis Ababa, Ethiopia;1. Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan;2. Seisen University, Research Institute for Cultural Studies, 3-16-21 Higashi Gotanda, Shinagawa-ku, Tokyo 141-8642, Japan;3. Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan;1. University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, 11000, Belgrade, Serbia;2. Department of Endocrinology, Faculty of Medicine, University Hospital Zemun, Belgrade, Serbia;3. Institute of Public Health of Serbia “Dr Milan Jovanovic Batut”, Belgrade, Serbia;4. Blood Transfusion Institute, Belgrade, Serbia |
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| Abstract: | BackgroundHuman biomonitoring studies of trace elements in biological fluids are mostly limited to a certain number of elements or biological materials. In this study, we describe the significant extension of a biomonitoring to 73 elements being present in concentration ranges from ng/L to g/L in clinically relevant specimens such as blood, serum, erythrocytes and urine.MethodsThe samples were collected from 102 occupationally non-exposed inhabitants of northern Germany. The elements were determined either by inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) in the low concentration range or by inductively coupled plasma optical emission spectrometry (ICP-OES) for essential trace elements and electrolytes.ResultsMean values and selected percentiles of element concentrations are presented for all sample materials. From the results, we calculated the distribution of elements between plasma and blood cells. Application of ICP-MS/MS improves selectivity and accuracy in the determination of elements that are strongly spectrally interfered, such as Cr, Ge, Pd or Ti in blood samples.ConclusionsThis publication provides very valuable information for occupational or environmental hygienists, toxicologists and clinical chemists due to the particularly high number of determined elements and presented concentration ranges. |
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| Keywords: | Trace elements Biomonitoring Blood Serum Urine Erythrocytes ICP-MS ICP-OES |
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