A follow-up study of mucociliary clearance and trace element and mineral status in children with chronic rhinosinusitis before and three months after endoscopic sinus surgery |
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| Institution: | 1. Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech, St. Petersburg, Russia;2. I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russia;3. K.A. Raukhfus Children''s City Multidisciplinary Clinical Center for High Medical Technologies, St. Petersburg, Russia;4. First Pavlov State Medical University of Saint Petersburg, St. Petersburg, Russia;5. National Center of Morphological Diagnostic, St. Petersburg, Russia;6. Institute of General Pathology and Pathophysiology, Moscow, Russia;7. I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;8. K.G. Razumovsky Moscow State University of Technologies and Management, Moscow, Russia;9. Yaroslavl State University, Yaroslavl, Russia;1. Center for Advanced Studies and Technology (C.A.S.T.), \"G. d''Annunzio\" University of Chieti-Pescara, Via Luigi Polacchi 11, Chieti, I-66100, Italy;2. Department of Physics, Università Degli Studi di Milano, Via Celoria 16, Milano, I-20133, Italy;3. LASA, Department of Physics, Università Degli Studi di Milano and INFN-Milano, Via F.lli Cervi 201, Segrate, MI, I-20090, Italy;4. Institute of Clinical Immunotherapy and Advanced Biological Treatments, Piazza Pierangeli 1, Pescara, Rectorate of Leonardo da Vinci Telematic University, Largo San Rocco 11 Torrevecchia Teatina, CH, Italy;5. Department of Medicine and Aging Sciences, \"G. d''Annunzio\" University of Chieti-Pescara, via Luigi Polacchi 11, Chieti, I-66100, Italy;1. Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, 530021, China;2. Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China;3. Atmospheric Environment Research Center, Scientific Research Academy of Guangxi Environmental Protection, Nanning, 530022, China;4. Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Department of Environmental Science and Engineering, Fudan University, Shanghai, 200433, China;5. Department of Preventive Medicine, School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, 530200, China;6. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, United States;1. Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, and Ministry of Education (MOE) Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, PR China;2. Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong Province, 518051, PR China;1. Laboratório de Toxicologia Celular, Departamento de Biologia Celular, Universidade Federal do Paraná, CEP 81.531-980, Curitiba, PR, Brazil;2. Laboratório Fotonanobio, Departamento Acadêmico de Física, Universidade Tecnológica Federal do Paraná, CEP 80.230-901, Curitiba, PR, Brazil;3. Laboratório de Células Inflamatórias e Neoplásicas, Departamento de Biologia Celular, Universidade Federal do Paraná, CEP 81.531-980, Curitiba, PR, Brazil;1. Center for Advanced Studies and Technology (C.A.S.T.), “G. d''Annunzio” University of Chieti-Pescara, Via Luigi Polacchi 11, Chieti, I-66100, Italy;2. Department of Physics, Università Degli Studi di Milano, Via Celoria 16, Milano, I-20133, Italy;3. LASA, Department of Physics, Università Degli Studi di Milano and INFN-Milano, Via F.lli Cervi 201, Segrate, MI, I-20090, Italy;4. Institute of Clinical Immunotherapy and Advanced Biological Treatments, Piazza Pierangeli 1, Pescara, Italy;5. Rectorate of Leonardo da Vinci Telematic University, Largo San Rocco 11 Torrevecchia, Teatina, CH, Italy;6. Department of Medicine and Aging Sciences, “G. d’Annunzio” University of Chieti-Pescara, via Luigi Polacchi 11, Chieti, I-66100, Italy |
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| Abstract: | BackgroundThe existing data demonstrate the potential role of trace elements in nasal mucociliary clearance, although the association between trace element and mineral status and ciliary function in children with chronic rhinosinusitis is insufficiently studied. Therefore, the objective of the present study is evaluation of trace element and mineral status and mucociliary function in pediatric CRS patients before and after functional endoscopic sinus surgery.MethodsThe present study involved 30 children with chronic rhinosinusitis without nasal polyps. During this follow-up the patients were examined preoperatively (point 0), underwent functional endoscopic sinus surgery, and were repeatedly examined at three months postoperatively (point 1). At both points the patients were subjected to quality-of-life assessment using SNOT-20 questionnaire; endoscopic and computer tomography examination of the nasal sinuses; evaluation of ciliary function and mucosal cytology using high-speed videomicroscopy; assessment of blood count and inflammatory markers; as well as analysis of trace element and mineral levels in whole blood, serum, and hair using inductively-coupled plasma mass-spectrometry.ResultsThe obtained data demonstrate that endoscopic sinus surgery significantly improved sinonasal pathology in children with chronic rhinosinusitis, as evidenced by significantly reduced Lund-Mackay, Lund-Kennedy, and SNOT-20 scores. At the same time, no significant improvement of ciliary functions or mucosal cytology was observed postoperatively. Trace element status assessment demonstrated that postoperative serum Zn, whole blood Mg and Cu were significantly lower as compared to preoperative values. In contrast, serum Mn and Cr, as well as whole blood Cr and hair Se were characterized by a significant increase at three months postoperatively. Multiple linear regression analysis demonstrated that serum Zn is significantly associated with the number of ciliated cells and cell viability, whereas serum Mn and whole blood Cu concentrations are inversely associated with cell viability and ciliary length, respectively. Hair Se was found to be associated with the number of neutrophils in the mucosa biopsy.ConclusionRedistribution of trace elements and minerals may at least partially mediate prolonged recovery of mucosal ciliary function in children with chronic rhinosinusitis in three months after functional sinus surgery, although the particular mechanisms of these alterations in trace element levels are to be discovered. |
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| Keywords: | Chronic rhinosinusitis Ciliary function Zinc Manganese Recovery |
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