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Refactoring biosynthetic gene clusters for heterologous production of microbial natural products
Affiliation:1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, USA;2. Center for Microbiome Innovation, University of California, San Diego, USA;1. Department of Bioengineering and Therapeutic Sciences and the California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94158, USA;2. Department of Microbial Physiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 7, 9747AG Groningen, The Netherlands;3. Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 7, 9747AG Groningen, The Netherlands;4. Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA;5. Department of Chemistry, Indiana University, Bloomington, IN 47405, USA;6. US Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USA;7. The Broad Institute, Cambridge, MA 02142, USA;8. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;9. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA;1. Department Microbial Natural Products, Actinobacteria Metabolic Engineering Group, Saarland University, Campus C2.3, 66123 Saarbrücken, Germany;2. Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infectious Research (HZI), Germany;3. i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal;4. IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal;1. Department of Biomedical Science and Engineering, Konkuk University, Seoul, 05029, Republic of Korea;2. Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea
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