Sculpting the heart: Cellular mechanisms shaping valves and trabeculae |
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Affiliation: | 1. IGF, LabexICST, CNRS, INSERM, Univ Montpellier, Montpellier, France;2. Aix Marseille Univ, INSERM, GMGF, Marseille, France;3. Service de Chirurgie Cardiaque, AP-HM, Hôpital de la Timone, 13005 Marseille, France;4. Service de Cardiologie, AP-HM, Hôpital de la Timone, 13005 Marseille, France |
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Abstract: | The transformation of the heart from a simple tube to a complex organ requires the orchestration of several morphogenetic processes. Two structures critical for cardiac function, the cardiac valves and the trabecular network, are formed through extensive tissue morphogenesis—endocardial cell migration, deadhesion and differentiation into fibroblast-like cells during valve formation, and cardiomyocyte delamination and apico-basal depolarization during trabeculation. Here, we review current knowledge of how these specialized structures acquire their shape by focusing on the underlying cellular behaviors and molecular mechanisms, highlighting findings from in vivo models and briefly discussing the recent advances in cardiac cell culture and organoids. |
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