Regulation of biomolecular condensate dynamics by signaling |
| |
| Institution: | 1. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028, Barcelona, Spain;2. Joint BSC-IRB Research Programme in Computational Biology, Baldiri Reixac 10, 08028, Barcelona, Spain;3. ICREA, Passeig Lluís Companys 23, 08010, Barcelona, Spain;1. Department of Cell and Developmental Biology, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel;1. Department of Biophysics and Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX 75390, USA;2. Computational and Molecular Biophysics Graduate Program, Washington University in St. Louis, St. Louis, MO 63130, USA;3. Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA;4. Department of Chemistry and Chemical Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA;1. Department of Cell Biology, Department of Biophysics, UT Southwestern Medical Center, Dallas, TX 75390, USA;2. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany;3. Centre for Genomic Regulation (CRG), Barcelona Institute for Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain;4. Universitat Pompeu Fabra (UPF), Barcelona, Spain;1. Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada;2. Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada |
| |
| Abstract: | Biomolecular condensates are mesoscopic biomolecular assemblies devoid of long range order that contribute to important cellular functions. They form reversibly, are stabilized by numerous but relatively weak intermolecular interactions, and their formation can be regulated by various cellular signals including changes in local concentration, post-translational modifications, energy-consuming processes, and biomolecular interactions. Condensates formed by liquid–liquid phase separation are initially liquid but are metastable relative to hydrogels or irreversible solids that have been associated with protein aggregation diseases and are stabilized by stronger, more permanent interactions. As a consequence of this, a series of cellular mechanisms are available to regulate not only biomolecular condensation but also the physical properties of the condensates. |
| |
| Keywords: | Liquid-liquid phase separation Biomolecular condensation Post-translational modifications Alternative splicing Maturation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
