Effects of boron-containing compounds in the fungal kingdom |
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| Affiliation: | 1. Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, Mexico;2. Unidad de Investigación, Hospital Regional de Alta Especialidad Ixtapaluca, Carretera Federal México-Puebla km 34.5, C.P. 56530, Ixtapaluca, State of Mexico, Mexico;3. BioBoron Research Institute, Dunarii 31B Street, 207465, Podari, Romania;1. Department of Chemistry, College of Science, University of Kufa, Iraq;2. Clinical Analysis Department, College of Pharmacy, Hawler Medical University, Havalan City, Erbil, Iraq;3. Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;4. Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria;5. IMPACT Strategic Research Centre, Deakin University, PO Box 281, Geelong, VIC, 3220, Australia;1. Department of Chemistry, Faculty of Science, University of Kerbala, Karbala, Iraq;2. ICP-MS Facility, Department of Chemistry, Faculty of Engineering and Physical Sciences, Guildford, Surrey, GU2 7XH, UK;1. Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Patología, Av. San Martín 5285, C1427CWO, Ciudad Autónoma de Buenos Aires, Argentina;2. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisicoquímica, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Bioquímica y Medicina Molecular (IBIMOL, UBA-CONICET), Junín 956, C1113AAD, Ciudad Autónoma de Buenos Aires, Argentina;1. Departamento de Química, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil;2. Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, 96160-000, Capão do Leão, RS, Brazil;3. Metallomics Center, Department of Chemistry, University of Cincinnati, 45221, Cincinnati, OH, USA;1. Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey;2. Department of Animal Nutrition and Nutritional Diseases, School of Veterinary Medicine, Erciyes University, Kayseri, Turkey;3. Department of Biology, Faculty of Science, Firat University, Elazig, Turkey;4. Research and Development, Nutrition 21, LLC, NY, United States |
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| Abstract: | BackgroundThe number of known boron-containing compounds (BCCs) is increasing due to their identification in nature and innovative synthesis procedures. Their effects on the fungal kingdom are interesting, and some of their mechanisms of action have recently been elucidated.MethodsIn this review, scientific reports from relevant chemistry and biomedical databases were collected and analyzed.ResultsIt is notable that several BCC actions in fungi induce social and economic benefits for humans. In fact, boric acid was traditionally used for multiple purposes, but some novel synthetic BCCs are effective antifungal agents, particularly in their action against pathogen species, and some were recently approved for use in humans. Moreover, most reports testing BCCs in fungal species suggest a limiting effect of these compounds on some vital reactions.ConclusionsNew BCCs have been synthesized and tested for innovative technological and biomedical emerging applications, and new interest is developing for discovering new strategic compounds that can act as environmental or wood protectors, as well as antimycotic agents that let us improve food acquisition and control some human infections. |
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| Keywords: | Boron Boronic acids Fungi Antifungals Human mycosis Crystal proteins |
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