Impact of the ‘tubulin economy’ on the formation and function of the microtubule cytoskeleton |
| |
| Institution: | 1. Department of Cell and Developmental Biology, University of Michigan, USA;2. Department of Cell and Developmental Biology, Vanderbilt University, USA;3. Department of Biomolecular and Chemical Engineering, Department of Biochemistry, Vanderbilt University, USA;1. Biology Department, University of North Carolina, Chapel Hill, NC, 27599, USA;2. Marine Biological Laboratory, Woods Hole, MA, 02543, USA;1. Department of Pediatrics, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA;2. Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO, USA;3. Department of Biomedical Engineering and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA;1. Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, United States;2. Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37240, United States;3. Department of Biochemistry, Vanderbilt University, Nashville, TN 37240, United States;1. Graduate Program in Cancer Biology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA;2. Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA;3. Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA;4. Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, 48109, USA |
| |
| Abstract: | The microtubule cytoskeleton is assembled from a finite pool of α,β-tubulin, the size of which is controlled by an autoregulation mechanism. Cells also tightly regulate the architecture and dynamic behavior of microtubule arrays. Here, we discuss progress in our understanding of how tubulin autoregulation is achieved and highlight work showing that tubulin, in its unassembled state, is relevant for regulating the formation and organization of microtubules. Emerging evidence suggests that tubulin regulates microtubule-associated proteins and kinesin motors that are critical for microtubule nucleation, dynamics, and function. These relationships create feedback loops that connect the tubulin assembly cycle to the organization and dynamics of microtubule networks. We term this concept the ‘tubulin economy’, which emphasizes the idea that tubulin is a resource that can be deployed for the immediate purpose of creating polymers, or alternatively as a signaling molecule that has more far-reaching consequences for the organization of microtubule arrays. |
| |
| Keywords: | Tubulin Kinesin Microtubule Dynamics Cytoskeleton |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
