A comprehensive review of the functions of YB-1 in cancer stemness,metastasis and drug resistance |
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| Affiliation: | 1. Nephrology and Clinical Immunology, RWTH University of Aachen, Aachen, Germany;2. Pneumology, University Medical Center, University of Freiburg, Freiburg, Germany;3. Nephrology and Hypertension, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany;1. Laboratory of Biochemistry, School of Pharmacy, Nihon University, Narashinodai, Funabashi, Chiba, 274-8555, Japan;2. Laboratory of Bio-organic Chemistry, School of Pharmacy, Nihon University, Narashinodai, Funabashi, Chiba, 274-8555, Japan;1. Department of Oncology, Huai''an First People''s Hospital, Nanjing Medical University, Huai''an, Jiangsu, China;2. Nanjing Medical University Affliated Cancer Hospital, Department of Clinical Cancer Research Center, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, Jiangsu, China;3. Department of Pathology, Huai''an First People''s Hospital, Nanjing Medical University, Huai''an, Jiangsu, China;4. Department of Otolaryngology, Huai''an First People''s Hospital, Nanjing Medical University, Huai''an, Jiangsu, China;1. Department of Pathology, Affiliated Cancer Hospital of Nantong University, Nantong 226361, Jiangsu, China;2. Department of Pathogen, Medical College, Nantong University, Nantong 226001, Jiangsu, China;3. Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, Jiangsu, China;4. Department of Oncology, Affiliated Cancer Hospital of Nantong University, Nantong 226361, Jiangsu, China;1. Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province 226001, PR China;2. Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province 226001, PR China;3. Department of General Surgery, The First People''s Hospital of Nantong, Jiangsu Province 226001, PR China |
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| Abstract: | The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain protein family with multifunctional properties both in the cytoplasm and inside the nucleus. YB-1 is also involved in various cellular functions, including regulation of transcription, mRNA stability, and splicing. Recent studies have associated YB-1 with the regulation of the malignant phenotypes in several tumor types. In this review article, we provide an in-depth and expansive review of the literature pertaining to the multiple physiological functions of YB-1. We will also review the role of YB-1 in cancer development, progression, metastasis, and drug resistance in various malignancies, with more weight on literature published in the last decade. The methodology included querying databases PubMed, Embase, and Google Scholar for Y box binding protein 1, YB-1, YBX1, and Y-box-1. |
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