Associations between blood metal/ metalloid concentration and human semen quality and sperm function: A cross-sectional study in Hong Kong |
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| Institution: | 1. Assisted Conception Unit, Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China;2. Center for Reproductive Medicine, Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, People’s Republic of China;3. Consortium on Health, Environment, Education and Research (CHEER), Department of Science and Environmental Studies, The Education University of Hong Kong, Hong Kong, People’s Republic of China;4. School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen, People’s Republic of China;1. Department of Chemistry, Faculty of Science, University of Kerbala, Karbala, Iraq;2. ICP-MS Facility, Department of Chemistry, Faculty of Engineering and Physical Sciences, Guildford, Surrey, GU2 7XH, UK;1. Department of Life and Environmental Sciences, Polytechnic University of Marche, 60131, Ancona, Italy;2. School of Pharmacy, University of Camerino, Camerino, MC, Italy;3. School of Pharmacy and Health Products, University of Camerino, 62032, Camerino, Italy;1. Zoology Department, Faculty of Science, Cairo University, Egypt;2. Biology Department, Faculty of Science, King Khalid University, Abha, Saudi Arabia;3. Blood Products Quality Control and Research Department, National Organization for Research and Control of Biologicals, Cairo, Egypt;1. Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey;2. Department of Animal Nutrition and Nutritional Diseases, School of Veterinary Medicine, Erciyes University, Kayseri, Turkey;3. Department of Biology, Faculty of Science, Firat University, Elazig, Turkey;4. Research and Development, Nutrition 21, LLC, NY, United States;1. School of Public Health, Changsha Medical University, Changsha, Hunan, PR China;2. The 169th Hospital of People''s Liberation Army, Xiangnan Affiliated Hospital of Hunan Normal University, Hengyang, Hunan, PR China;3. Department of Preventive Medicine, School of Public Health, University of South China, Hengyang, Hunan, PR China;4. Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;5. Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;1. School of Public Health, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei 110, Taiwan;2. Department of Obstetrics and Gynecology, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei 110, Taiwan;3. Department of Obstetrics and Gynecology, Taipei Medical University Hospital, No. 252, Wuxing St., Xinyi Dist., Taipei 110, Taiwan |
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| Abstract: | BackgroundThe association between metal/metalloid exposure on human sperm quality is still inconclusive. There is a lack of data on the effect of metal/metalloid on sperm function.MethodsThe aim of this study was to clarify the association between blood metal/metalloid concentration and traditional and functional sperm parameters, the blood concentration of Pb, Hg, Cd, As, Ni, Mo, Zn, Cu, Se, Fe, Mg, Cr and Ca of 288 men in Hong Kong were assessed by inductively coupled plasma-mass spectrometry, and sperm parameters including sperm concentration, motility, morphology, vitality, total sperm count, total motile sperm count, sperm DNA fragmentation and sperm acrosome reaction were measured. Demographic and lifestyle questionnaires were also provided for all participants. Multivariable linear regression analysis was performed to test the association between blood metal/ metalloid concentration and semen parameters after adjusting for relevant confounding variables.ResultsThe results showed that moderate to high level of blood Pb concentration (>27.19 μg/L) appeared to be negatively associated with sperm morphology (P < 0.05); high level of blood Cd concentration (>1.44 μg/L) was negatively associated with sperm acrosome reaction (P < 0.05); Mo was positively associated with semen volume (P < 0.05), however, high level of blood Mo concentration (>13.52 μg/L) was negatively associated with sperm vitality (P < 0.05); high level of blood Zn concentration (>6.20 mg/L) was positively associated with sperm vitality (P < 0.05); moderate level of blood Fe concentration (526.89?566.63 mg/L) was positively associated with sperm acrosome reaction (P < 0.05); moderate level of blood Ca concentration (55.92?66.10 mg/L) was positively associated with semen volume (P < 0.05); however, lower level of blood Ca concentration (45.90?55.92 mg/L) was negatively associated with sperm morphology (P < 0.05).ConclusionsOur results suggested that the sperm function could be affected by blood Cd and Fe concentration and traditional sperm parameters could be affected by blood concentration of Mo, Zn, Pb and Ca. |
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| Keywords: | Heavy metals Sperm function Semen analysis Acrosome reaction |
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