Association of newborn blood lead concentration with neurodevelopment outcome in early infancy |
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| Institution: | 1. Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, 342005, India;2. WQMG/DEST Division, Defence Research and Development Organization, Jodhpur, 342011, India;3. Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, 342005, India;4. Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 342005, India;5. Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, 342005, India;1. ‘Jo?ef Stefan’ Institute, Department of Environmental Sciences, Ljubljana, Slovenia;2. Ex-Department of Occupational Health, Idrija Mercury Mine, Idrija, Slovenia;3. University Medical Centre Ljubljana, Clinical Institute of Clinical Chemistry and Biochemistry, Ljubljana, Slovenia;4. University Medical Centre Ljubljana, Division of Paediatrics, Department of Child, Adolescent and Developmental Neurology, Slovenia;5. University in Ljubljana, Faculty of Pharmacy, Slovenia;6. University Hospital Centre Rijeka, Department of Paediatrics, Rijeka, Croatia;7. OIKON, Institute for Applied Ecology, Zagreb, Croatia;8. ‘Jo?ef Stefan’ International Postgraduate School, Ljubljana, Slovenia;1. Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Zografos, Panepistimiopolis, Athens, 15784, Greece;2. Laboratory of Environmental Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Zografos, Panepistimiopolis, Athens, 15784, Greece;3. General Hospital “LAIKO”, Athens, 11527, Greece;1. Gangarosa Department of Environmental Health, Emory University, Atlanta, GA, USA;2. Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA;3. Department of Earth Sciences, Dartmouth College, Hanover, NH, USA;4. Department of Biological Sciences, Dartmouth College, Hanover, NH, USA;5. Department of Pediatrics, Women & Infants Hospital of Rhode Island, Providence, RI, USA;6. The Brown Center of the Study of Children at Risk, Brown University, Providence, RI, USA |
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| Abstract: | BackgroundIn utero exposure to toxic metal substances can cause severe neurodevelopmental deficits in developing fetus and infant.MethodsWe evaluated the association of newborn umbilical cord blood lead concentration with early neurodevelopmental performance (cognitive, receptive language, expressive language, fine motor, gross motor and social-emotional development). The Bayley Scale of Infants Developments-III (BSID-III) was used to perform neurodevelopment outcomes at an average age of 6.5 months. In this prospective study, total of 167 mother-child pairs were enrolled from Western Rajasthan, India. Association between risk factors of lead contamination and newborn umbilical cord blood lead levels was observed. Multivariate regression was performed to see the association of cord blood lead level with infant neurodevelopment outcome.ResultsThe obtained newborn umbilical cord blood lead concentration 5.0–10.5 μg/dL was negatively associated with the sub-scale score of gross motor development (β-coefficient with 95 % CI; ?0.29 (?5.0–0.11), p = 0.04). However, no associations were found with the score of cognitive, language, gross motor, and social-emotional development. The umbilical cord blood lead concentration <5.0 μg/dL was also not associated with the BSID-III scores. The mother's regular intake of calcium supplements during the antenatal period was significantly associated with a lower umbilical cord blood lead level (p-value 0.031).ConclusionThe data suggest that newborn umbilical cord blood lead concentration 0.5–10.5 μg/dL has a negative association with early gross motor development during infancy. |
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| Keywords: | Neurodevelopment Infant Newborn Lead Umbilical cord blood |
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