A spatial study on serum selenoprotein P and Keshan disease in Heilongjiang Province,China |
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| Affiliation: | 1. Department of Chemistry, College of Science, University of Kufa, Iraq;2. Clinical Analysis Department, College of Pharmacy, Hawler Medical University, Havalan City, Erbil, Iraq;3. Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;4. Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria;5. IMPACT Strategic Research Centre, Deakin University, PO Box 281, Geelong, VIC, 3220, Australia;1. Department of Chemistry, Faculty of Science, University of Kerbala, Karbala, Iraq;2. ICP-MS Facility, Department of Chemistry, Faculty of Engineering and Physical Sciences, Guildford, Surrey, GU2 7XH, UK;1. Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Patología, Av. San Martín 5285, C1427CWO, Ciudad Autónoma de Buenos Aires, Argentina;2. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisicoquímica, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Bioquímica y Medicina Molecular (IBIMOL, UBA-CONICET), Junín 956, C1113AAD, Ciudad Autónoma de Buenos Aires, Argentina;1. Department of Chemical Sciences, Faculty of Science, University of Johannesburg, PO Box 17011, Doornfontein, Johannesburg, South Africa;2. Department of Chemistry, School of Sciences, The Federal University of Technology, PMB 704, Akure, Ondo State, Nigeria;3. Department of Biotechnology and Food Technology, Faculty of Science, University of Johannesburg, PO Box 17011, Doornfontein, Johannesburg, South Africa;4. Department of Food Science and Technology, Kwara State University, PMB 1530, Malete, Ilorin, Kwara State, Nigeria;1. Zoology Department, Faculty of Science, Cairo University, Egypt;2. Biology Department, Faculty of Science, King Khalid University, Abha, Saudi Arabia;3. Blood Products Quality Control and Research Department, National Organization for Research and Control of Biologicals, Cairo, Egypt;1. Department of Pediatric Dentistry, Poznań University of Medical Sciences, 70 Bukowska St, 60-812 Poznań, Poland;2. Postgraduate Studies in Scientific Research Methodology, Poznań University of Medical Sciences, 70 Bukowska St, 60-812 Poznań, Poland;3. Institute of Chemistry and Technical Electrochemistry, Poznan University of Technology, 4 Bedrychowo St, 60-965 Poznan, Poland |
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| Abstract: | BackgroundFew spatial studies on serum selenoprotein P (SELENOP) and Keshan disease (KD) have been reported at the county-level in Heilongjiang province, China. This study aimed to provide visualized spatial epidemiological evidence of selenium molecular marker in residents living in endemic areas for the precise assessment of prevention, control, and elimination of KD.MethodsUsing a spatial ecological study design, 587 subjects living in cities, townships, and rural areas of 50 KD endemic counties and 37 non-endemic counties in Heilongjiang province were investigated. The serum SELENOP levels of the participants were measured by enzyme-linked immunosorbent assay. Thematic maps were created, and spatial regression analysis was conducted using ordinary least squares.ResultsThe mean serum SELENOP level of the 587 subjects was 7.4 ± 3.0 μg/mL. The mean levels of serum SELENOP were higher in cities (7.4 ± 2.9 μg/mL) and townships (7.9 ± 3.2 μg/mL) than in rural areas (6.0 ± 3.0 μg/mL). The mean levels of serum SELENOP were trending towards high levels in non-endemic areas (7.4 ± 3.0 μg/mL) than in KD endemic areas (6.3 ± 3.3 μg/mL). Spatial regression analysis showed that the serum SELENOP level was positively correlated with the per capita gross domestic product.ConclusionSelenium deficiency may still exist in some KD endemic counties in Heilongjiang province, including Lingdong, Nenjiang, and Baiquan; these counties should be considered as key areas for precision prevention, control, and elimination of KD. Inclusion of selenium in the national surveillance of KD will provide more evidence for the assessment of KD elimination from a selenium nutrition perspective. |
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| Keywords: | Selenoprotein P Spatial epidemiology Selenium Keshan disease Precision Public health |
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