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Mercury complexes of thionicotinamide adenine dinucleotide
Authors:Marc S. Weininger  Leonard J. Banaszak
Affiliation:Department of Biological Chemistry, Division of Biology and Biomedical Sciences, Washington University, St. Louis, Mo. 63110 USA
Abstract:One-to-one mercury complexes of thionicotinamide adenine dinucleotide (TNAD+) were prepared by using HgSO4 and Hg(CH3 COO?)2. Optical absorption spectroscopy indicated that the mercury probably binds to the TNAD+ through the thio-keto group on the pyridine ring. X-ray diffraction patterns of crysltals of mitichondrial malate dehydrogenase soaked in solution containing TNAD+ · mercury complex indicated binding and the X-ray intensity differences are different from mercurials alone.
Keywords:thionicotinamide adenine dinucleotide  m-MDH  mitochondrial malate dehydrogenase  m-βHADH  mitochondrial L-3-hydroxacyl coenzyme A dehydrogenase
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