Transient and long-term differential modulations of branched-chain α-keto acid decarboxylase activity in hypophysectomized rats |
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| Authors: | Stephen Gene Sullivan Joseph Dancis Rody P Cox |
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| Institution: | Division of Human Genetics, Departments of Medicine, Pharmacology and Pediatrics, New York University Medical Center, New York, N.Y. 10016, U.S.A. |
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| Abstract: | Hypophysectomy caused a marked but transient increase in branched-chain α-keto acid decarboxylase activities in rat liver mitochondria, peaking at about nine days post-surgery. The magnitude of increase is different for each of the three branched-chain α-keto acids. The activities then fall to a new steady state in three weeks with α-ketoisovalerate decarboxylase activity within the normal range, α-keto-β-methylvalerate decarboxylase activity at twice normal, and α-ketoisocaproate decarboxylase activity decreased to a level too low for accurate measurements. |
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