Glutathione reductase functions as vanadate(V) reductase |
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Authors: | X L Shi N S Dalal |
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Affiliation: | Department of Chemistry, West Virginia University, Morgantown 26505. |
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Abstract: | The oxidation of NADPH by vanadate(V) in the presence of glutathione reductase showed typical enzymatic kinetics. The oxidation was inhibited by N-ethylmaleimide, a glutathione reductase inhibitor. Superoxide dismutase had no significant effect on the oxidation, indicating noninvolvement of the superoxide radical. The vanadate(V) reduction was found to be a one-electron transfer process. These results suggest a new pathway for vanadate(V) metabolism and a new function of glutathione reductase. |
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