The finite polygenic mixed model: An alternative formulation for the mixed model of inheritance |
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| Authors: | R L Fernando C Stricker R C Elston |
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| Institution: | (1) Department of Animal Sciences, University of Illinois at Urbana-Champaign, 1207 West Gregory Drive, 61801 Urbana, IL, USA;(2) Department of Biometry and Genetics and the Center for Molecular and Human Genetics, Louisiana State University, Medical Center, 1901 Perdido Street, 70112-1393 New Orleans, USA |
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| Abstract: | This paper presents a mixed model of inheritance with a finite number of polygenic loci. This model leads to a likelihood that can be calculated using efficient algorithms developed for oligogenic models. For comparison, likelihood profiles were obtained for the finite polygenic mixed model, the usual mixed model, with exact and approximate calculations, and for a class D regressive model. The profiles for the finite polygenic mixed model were closest to the profiles for the usual mixed model with exact calculations. |
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| Keywords: | Mixed model inheritance Likelihood |
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