Synthesis of ABO histo-blood group type I and II antigens |
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Authors: | Peter J. Meloncelli |
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Affiliation: | Department of Chemistry and Alberta Ingenuity Centre for Carbohydrate Science, Gunning-Lemieux Chemistry Centre, University of Alberta, Edmonton, AB, Canada T6G 2G2 |
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Abstract: | The ABO histo-blood group system is one of the most clinically important antigen families. As part of our overall goal to prepare the entire set of the A, B and H type I-VI antigens for a range of biochemical investigations, we report herein the synthesis of the type I and II antigens with a 7-octen-1-yl aglycone. This linker was chosen to facilitate not only the future conjugation of the antigens to a protein or solid support but also the synthesis of the H type I and II octyl glycosides for enzyme kinetic studies. |
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Keywords: | ABO histo-blood group ABO type I ABO type II Chemical synthesis Trichloroacetimidate 7-Octen-1-yl |
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