Regioselective facile one-pot Friedländer synthesis of sugar-based heterocyclic biomolecules |
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| Authors: | Subbiah Nagarajan Nanjian Raaman |
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| Institution: | a Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India
b Fungal Biotechnology, Natural Products and Plant Tissue Culture Laboratory, Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai 600 025, India |
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| Abstract: | Regioselective facile one-pot synthesis of 16 different sugar-based quinoline, naphthyridine, and xanthone derivatives is reported. The compounds are characterized by NMR spectroscopy and elemental analysis. The β-Anomeric form of the sugar moiety was identified from 1H NMR studies. Antimicrobial studies of these sugar-heterocyclic derivatives, 3a, 3b, 3f, 5c, 7a, 7b, and 7c show excellent activity against different microbes. |
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| Keywords: | β-C-Glycosylic ketones Friedlä nder condensation Quinolines Naphthyridines Xanthones Antimicrobial activity |
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