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Synthesis and biological evaluation of glycal-derived novel tetrahydrofuran 1,2,3-triazoles by ‘click’ chemistry |
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| Authors: | L Vijaya Raghava Reddy Nripendra N Mishra Garima Yadav Arun K Shaw |
| Institution: | a Division of Medicinal and Process Chemistry, Central Drug Research Institute (CSIR), Lucknow 226 001, India b Division of Fermentation Technology, Central Drug Research Institute (CSIR), Lucknow 226 001, India c Division of Microbiology, Central Drug Research Institute (CSIR), Lucknow 226 001, India |
| Abstract: | Thirteen new 1,2,3-triazoles (5a-e, 15a-d, 17a-b, 19, and 21) were synthesized by ‘click’ reaction of sugar-derived azides with commercially available acetylenes. The synthesized triazoles were tested in vitro for their biological activity, and compound 5b displayed both antibacterial and antifungal activities at an MIC value of 12.5 μg/mL, while compounds 15b and 19 showed antibacterial activity at an MIC value of 25 μg/mL. |
| Keywords: | 1 2 3-Triazoles Click chemistry THF domain |
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