Exogeneous cyclic AMP blocks the muscarinic receptor-mediated intracellular Ca2+-release in the gastrulating chick embryo cells |
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| Authors: | Tiit Laasberg |
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| Affiliation: | (1) Institute of Chemical Physics and Biophysics, Estonian Academy of Sciences, USSR;(2) Laboratory of Molecular Genetic, Institut of Chemical Physics and Biophysics, Akaademia tee 23, 200026 Tallinn, Estonian SSR, USSR |
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| Abstract: | Summary Exogeneous cyclic AMP (cAMP, 10–8M), when added together with acetylcholine (ACh, 500  M) to dissociated chick embryo cells, blocked the ACh-stimulated increase in the level of cytosolic free Ca2+ ([Ca2+]i). This inhibiting action of exogeneous cAMP is probably mediated by intracellular cyclic GMP (cGMP) and cAMP. |
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| Keywords: | Chick embryo Gastrulation Exogeneous cAMP Muscarinic receptor Cytosolic free Ca2+ Intra-cellular cGMP |
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