Differences in variation of human immunodeficiency virus type 1 sequences from Henan and Shanghai regions of China |
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Authors: | Yin Chun-yu Lu Hong-zhou Jiang Wei-ming Maria Pia De Pasquale Hu Yue-kai Pan Xiao-zhang Weng Xin-hua Richard T. D’Aquila Tang Yi-Wei |
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Affiliation: | 1. Department of Infectious Diseases,Fudan University Huashan Hospital, Shanghai 200040,China;Department of Infectious Diseases, the Sixth People's Hospital, Hangzhou 310014, China 2. Department of Infectious Diseases,Fudan University Huashan Hospital, Shanghai 200040,China 3. Division of Infectious Diseases, Department of Medicine; Tennessee 37232, USA 4. Division of Infectious Diseases, Department of Medicine; Tennessee 37232, USA;Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA 5. Division of Infectious Diseases, Department of Medicine; Tennessee 37232, USA;Departments of Pathology; Tennessee 37232, USA |
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Abstract: | Illegally paid blood donation was a risk factor for HIV acquisition exclusively in Henan and Hubei Provinces of China, and not in Shanghai. Nucleotide sequences in the gag and env genes of HIV-1 were compared between isolates from Henan and Shanghai regions of China to test whether an expected higher degree of a common source of infections from this unique blood donation transmission risk would be evident as decreased variation among Henan isolates in an exploratory cross-sectional analysis. Among 38 isolates studied, 23 of 23 (100%) from Henan and 8 of 15 (54%) from Shanghai were subtype B. In addition, fewer sequence differences were found in gp41 of subtype B isolates from Henan than from Shanghai isolates. Further studies with additional controls are therefore warranted to confirm the role of the degree of a common source of infections in differences in HIV variation across populations. Fundation items: The Vanderbilt-Meharry Center for AIDS Research (P30 AI 54999); R.T.D (R01 AI 29193); Start Fund of Ministry of Education of China (for Hong-zhou LU, 2004BA719A10). |
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Keywords: | HIV Transmission Phylogenetic analysis |
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