A case report of immunotherapy on a patient with advanced gastric cancer by adoptive transfer of OK-432-reactive HLA-matched allogeneic lymphocytes |
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Authors: | H Yamagishi Yuji Ueda Takahiro Oka |
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Institution: | (1) Second Department of Surgery, Kyoto Prefectural University of Medicine Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602, Japan Fax: +81 75 223 6189, JP |
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Abstract: | Adoptive immunotherapy (AIT) for non-hematological malignancies, using HLA-matched donor lymphocytes, has been rarely reported.
For a 35-year-old male patient with peritoneal disseminated advanced gastric cancer, we performed AIT using lymphocytes from
his HLA-matched 37-year-old brother and a streptococcal preparation, OK-432, as an antigen. After the donor had been immunized
by intradermal administration of OK-432, OK-432-reactive lymphocytes were induced in vitro and transferred to the patient
intravenously with OK-432. Low-dose systemic immunochemotherapy, using interleukin-2, 5-fluorouracil and cyclophosphamide,
was concurrently administered with AIT. As a result, the Schnitzler metastasis in the patient reduced in size without any
significant graft-versus-host-related complications. One of the effector mechanisms of therapeutic benefit was suggested to
be cytokine release from the transferred OK-432-reactive lymphocytes. Our findings suggest the safety and efficacy of AIT
using lymphocytes from an HLA-matched sibling and OK-432 as an antigen. Further studies to investigate the use of tumor-associated
antigen and an HLA-matched sibling’s lymphocytes for AIT of advanced cancer are warranted.
Received: 19 May 1997 / Accepted 18 November 1997 |
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Keywords: | Adoptive immunotherapy Allogeneic cell therapy Gastric cancer OK-432 Interleukin-2 (IL-2) |
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