(1) Unitat de Genètica Molecular, Hospital de la Santa Creu i Sant Pau, Av. Sant Antoni Maria Claret 167, E-08025 Barcelona, Spain;(2) Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, E-08071 Barcelona, Spain
Abstract:
Arrestin is a component of the light transduction cascade that takes place in the outer segment of retinal rods. In situ hybridization and linkage analysis have localized the arrestin gene to a region of 50 cM between CRYG and D2S23/D2S55 on chromosome 2q24–37. We have performed pairwise and multipoint linkage analysis between arrestin and four highly polymorphic markers from this region. The results indicate tight linkage between the gene and the microsatellite D2S172 (Zmax= 9.25 at =0.038). This fine localization of the gene should provide a useful tool for cosegregation analyses involving the arrestin gene.