Synthesis and in vitro leishmanicidal activity of 2-(5-nitro-2-furyl) and 2-(5-nitro-2-thienyl)-5-substituted-1,3,4-thiadiazoles |
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Authors: | Foroumadi Alireza Pournourmohammadi Shirin Soltani Fatemeh Asgharian-Rezaee Mitra Dabiri Shahriar Kharazmi Arsalan Shafiee Abbas |
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Affiliation: | Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman 76351, Iran. |
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Abstract: | A series of 2-(5-nitro-2-furyl) and 2-(5-nitro-2-thienyl)-5-substituted-1,3,4-thiadiazoles (5a-d and 6a-j) were synthesized and evaluated against Leishmania major promastigotes using (3)H-thymidine incorporation. Most of the compounds showed activity better than the reference drug sodium stibogluconate (Pentostam). The most active compound was 6c (IC(50)=0.1 microM). |
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