Suppression by Hydrangeae Dulcis Folium of D-galactosamine-induced liver injury in vitro and in vivo |
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Authors: | Nakagiri Ryusuke Hashizume Erika Kayahashi Shun Sakai Yasushi Kamiya Toshikazu |
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Institution: | Kyowa Hakko Kogyo Co., Ltd., Tsukuba Research Laboratories, Ibaraki, Japan. ryuusuke.nakagiri@kyowa.co.jp |
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Abstract: | Hydrangeae Dulcis Folium, the fermented and dried leaves of Hydrangea macrophylla SER. var. thunbergii MAKINO, suppressed D-galactosamine-induced liver injury by 85.2% when added to the diet at 1% and fed to rats for fifteen days. The hepatoprotective effect is more potent than that of a milk thistle extract and turmeric powder. Some fractionated extracts showed hepatoprotective activity in the D-galactosamine-induced in vitro liver injury model. |
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