| 精制Vero细胞狂犬病疫苗的灭活和纯化 |
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| 引用本文： | 吕宏亮,宋继萍,段招军,邹勇,沈心亮,王玉琳,周书全.精制Vero细胞狂犬病疫苗的灭活和纯化[J].病毒学报,2001,17(3):236-239. |
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| 作者姓名： | 吕宏亮 宋继萍 段招军 邹勇 沈心亮 王玉琳 周书全 |
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| 作者单位： | 1. 中国预防医学科学院病毒学研究所
2. 兰州生物制品研究所 |
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| 摘 要： | 通过狂犬病病毒灭活和纯化试验，试验精制Vero细胞狂犬病疫苗。疫苗经检测残余小牛血清白蛋白含量，Vero细胞残余DNA含量，疫苗效价，安全试验均能达到WHO规程要求。初步建立了适合大规模生产精制Vero细胞狂犬病疫苗的灭活和纯化工艺。
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| 关 键 词： | Vero细胞狂犬病疫苗 灭活 纯化 |
| 文章编号： | 10008721(2001)03-0236-04 |
Research on Procedures of Inactivation and Purification for Purifying Vero Cell Rabies Vaccine |
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| LV Hong liang ,SONG Ji ping ,DUAN Zhao jun ,ZOU Yong ,SHEN Xin liang ,WANG Yu ling ,ZHOU Shu quan.Research on Procedures of Inactivation and Purification for Purifying Vero Cell Rabies Vaccine[J].Chinese Journal of Virology,2001,17(3):236-239. |
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| Authors: | LV Hong liang SONG Ji ping DUAN Zhao jun ZOU Yong SHEN Xin liang WANG Yu ling ZHOU Shu quan |
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| Institution: | LV Hong liang 1,SONG Ji ping 2,DUAN Zhao jun 1,ZOU Yong 2,SHEN Xin liang 2,WANG Yu ling 2,ZHOU Shu quan 2 |
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| Abstract: | The procedure of inactivation and purification for purifying Vero cell rabies vaccine(PVRV)was explored by studying on inactivation with beta propiolactone(BPL),and purification with chromatography.The residual calf serum contents,residual Vero cell DNA contents,potency and safety tests of the purified Vero cell rabies vaccine prepared with this procedure all met the WHO Requirements of Biological Products(Edition 1986),so this procedure of inactivation and purification was available for large scale production of purified Vero cell rabies vaccine. |
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| Keywords: | Vero cell rabies vaccine inactivation purification |
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