Changes in the hypothalamo-pituitary-adrenocortical and hypothalamo-pituitary-thyroid axes in diabetic rats acclimated to moderate hyperthermic environment |
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| Authors: | Suzana Dinevska-Kjovkarovska Teuta Guladin Biljana Miova Slavco Mitev Katerina Gerazova |
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| Institution: | 1. Department of Physiology and Biochemistry, Faculty of Natural Sciences and Mathematics, Gazi Baba bb, 1000 Skopje, Republic of Macedonia;2. State University of Tetovo, Republic of Macedonia |
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| Abstract: | We examined the effect of acclimation to moderate hyperthermic environment on the ACTH, TSH, T3, T4 and corticosterone level, as well as the relative weight of hypophysis, thyroid and adrenal glands in streptozotocin-diabetic rats. Increased activity of the hypothalamo-pituitary-adrenocortical (HPA) axis has been demonstrated in diabetic animals, whereas insulin treatment restores the changes. Heat acclimation reduces the level of ACTH and corticosterone in control animals and moderates the hormonal disturbances caused by diabetes. Simultaneously, our study revealed impairment in the activity of the hypothalamo-pituitary-thyroid (HPT) axis. Acclimation to 35±1 °C resulted in significantly lower T3 and T4 levels in control, diabetic and insulin-treated animals. Relative weight of the hypophysis, thyroid and adrenal glands is decreased in heat-acclimated rats. Our assumption is that there might be a cross tolerance between diabetes and heat acclimation on a hormonal level. |
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| Keywords: | Experimental diabetes High environmental temperature Insulin ACTH Corticosterone TSH T3 T4 Endocrine glands Rats |
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