Neonatal asphyxia and hyperthermia and cognitive deficits in adult rats: Role of iron |
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| Authors: | Justyna Rogalska MichaŁ CaputaKatarzyna Piątkowska Anna Nowakowska |
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| Affiliation: | Department of Animal Physiology, Institute of General and Molecular Biology, N. Copernicus University, ul. Gagarina 9, 87-100 Toruń, Poland |
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| Abstract: | We compared effects of a critical neonatal anoxia, applied in Wistar rats at body temperatures of 33, 37 and 39 °C, on memory performance in adulthood. Because hyperthermic–anoxic neonates suffer from hyperferremia an additional group of rats, exposed to anoxia at 39 °C, was injected with deferoxamine, a chelator of iron. At the age of 4 and 12 months all rats were examined in hole board, typical maze and Morris maze. |
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| Keywords: | Rats Neonatal asphyxia Hyperthermia Iron Deferoxamine Behaviour Memory disturbances |
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