T-type Ca2+ channel blockers suppress the growth of human cancer cells |
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| Authors: | Heo Jae Ho Seo Han Na Choe Yun Jeong Kim Sujin Oh Chun Rim Kim Young Deuk Rhim Hyewhon Choo Dong Joon Kim Jungahn Lee Jae Yeol |
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| Institution: | aResearch Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul 130-701, Republic of Korea;bDongWoo Syntech Co., Ltd, Bondae-Ri Geumwang-Eup, Eumsung-Goon, Choongcheungbook-Do 369-901, Republic of Korea;cLife Sciences Division, Korea Institute of Science & Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea |
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| Abstract: | In order to further clarify the role of T-type Ca2+ channels in cell proliferation, we have measured the growth inhibition of human cancer cells by using our potent T-type Ca2+ channel blockers. As a result, KYS05090, a most potent T-type Ca2+ channel blocker, was found to be as potent as doxorubicin against some human cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type Ca2+ channel blocker presents new prospects for cancer treatment. |
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| Keywords: | T-type calcium channel blocker 3 4-Dihydroquinazoline Doxorubicin Anti-cancer |
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