病毒颗粒:药物靶向传递领域中的新型载体

由于具有高效靶向药物传递的潜力，病毒颗粒已成为药物和生命科学领域的研究焦点.病毒颗粒具有病毒性载体和非病毒性载体的优点，同时克服了两者的局限性.病毒颗粒药物传递系统具有无毒、生物相容性、生物可降解性和非自动免疫等特点.研究表明，病毒颗粒能够在细胞间转运多种具有生物活性的分子，例如核酸或者基因、多肽、蛋白质以及其它抗癌药物等，因此在疾病治疗方面可能具有重要作用.如何制备携带有生物活性材料和治疗试剂的病毒颗粒和确定病毒颗粒药物的最佳剂型是目前该领域中挑战性的课题.本文综述了病毒颗粒技术多方面的特征及应用前景.

Virosome: A Novel Vector in Targeted Drug Delivery

Virosome has been actively studied in pharmaceutical and life science fields for its potential in targeted drug delivery. Virosome has the advantages of both viral and non-viral vectors, avoiding various limitations of both. Virosome forms a non-autoimmunogenic drug delivery system that is nontoxic, biocompatible and biodegradable. Studies have shown that virosome was able to carry a variety of bioactive molecules,such as nucleic acids, peptides,or anti-cancer drugs, therefore could play an important role in disease treatments.Nonetheless, the preparation of virosome with bioactive materials and the therapeutic reagents to formulate virosomal drugs remain challenging. In this article, we briefly reviewed features of virosome and future prospects of this technology.