AMPA受体转运及其调控的分子机制

α-氨-3-羟基-5-甲基-4-异恶唑丙酸受体（α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors，AMPA receptors）介导中枢神经系统（CNS）绝大多数快兴奋性突触传递，在学习、记忆和认知等方面具有重要功能. 突触AMPA受体的数量、分布和亚基组成是调节突触传递强度的一个主要机制，与AMPA受体转运密切相关. 最新研究显示，异常的AMPA受体转运与阿尔茨海默病（Alzheimer’s disease，AD）、脆性X综合征(fragile X syndrome, FXS)等神经疾病有关. 本文主要针对AMPA受体转运及其调控的分子机制做一综述，以期为AD、FXS等神经疾病提供新的治疗靶点和途径.

Molecular Mechanisms of AMPA Receptors Trafficking and Its Regulation

α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (AMPA receptors) mediate the majority of fast excitatory synaptic transmission in the central nervous system (CNS) and have important functions in learning, memory, cognition, etc. One major mechanism that regulates synaptic strength involves the number, distribution and subunit composition of synaptic AMPARs and is closely related with AMPARs trafficking. The latest researches showed that aberrant AMPARs trafficking are involved in neurodegenerative diseases, such as Alzheimer’s disease （AD）. Here, we review recent findings about the molecular mechanisms of AMPA receptors trafficking and its regulation，to provide new therapeutic targets and approaches for AD and other neurodegenerative diseases.