Limonoids from the fruits of Melia toosendan |
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| Authors: | Zhang Yi Tang Chun-Ping Ke Chang-Qiang Li Xi-Qiang Xie Hua Ye Yang |
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| Institution: | Department of Natural Products Chemistry and Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China. |
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| Abstract: | Fifteen limonoids, meliatoosenins E-S (1-15), and 10 known compounds were isolated from the fruits of Melia toosendan. Their structures were elucidated on the basis of extensive spectroscopic methods including DEPT, HSQC, HMBC, (1)H-(1)H COSY, and ROESY experiments. All the compounds were evaluated for antiproliferative activity using A-549 and HL-60 cell lines. |
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