Antiamyloid properties of fullerene C60 derivatives

A comparative estimation of the ability of complexes of fullerene C₆₀ with polyvinylpyrrolidone and fullerene C₆₀ derivatives (the sodium salt of the polycarboxylic derivative of fullerene C₆₀, sodium fullerenolate), has been carried out. The fullerenes destroyed amyloid fibrils of the Aβ(1–42) peptide of the brain and the muscle X-protein. A study of the effect of fullerenes on muscle actin showed that complexes of fullerene C₆₀ with polyvinylpyrrolidone and sodium fullerenolate did not prevent the filament formation of actin, nor did they destroy its filaments in vitro. Conversely, sodium salt of the polycarboxylic derivative of fullerene C₆₀ destroyed actin filaments and prevented their formation. It was concluded that sodium fullerenolate and complexes of fullerene C₆₀ with polyvinylpyrrolidone are the most effective antiamyloid compounds among the fullerenes examined.