Tumour suppressor function of MDA-7/IL-24 in human breast cancer |
| |
| Authors: | Neill Patani Anthony Douglas-Jones Robert Mansel Wen Jiang Kefah Mokbel |
| |
| Institution: | (1) Department of Breast Surgery, The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, W1U-5NY London, UK;(2) Department of Medical Genetics, Haematology & Pathology, Cardiff University School of Medicine, Cardiff University, Heath Park, CF14-4XN Cardiff, UK;(3) Department of Surgery, Anaesthetics, Obstetrics & Gynaecology, Cardiff University School of Medicine, Cardiff University, Heath Park, CF14-4XN Cardiff, UK;(4) Metastasis & Angiogenesis Research Group, University Department of Surgery, Cardiff University School of Medicine, Cardiff University, Heath Park, CF14-4XN Cardiff, UK;(5) Department of Breast Surgery, St George's, University of London, SW17-0RE Cranmer Terrace, London, UK;(6) Department of Biosciences, School of Health Sciences and Social Care, Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, UB8 3PH Uxbridge, Middlesex, London, UK |
| |
| Abstract: | Introduction Melanoma differentiation associated gene-7 (MDA-7), also known as interleukin (IL)-24, is a tumour suppressor gene associated
with differentiation, growth and apoptosis. However, the mechanisms underlying its anti-neoplastic activity, tumour-specificity
and efficacy across a spectrum of human cancers have yet to be fully elucidated. In this study, the biological impact of MDA-7
on the behavior of breast cancer (BC) cells is evaluated. Furthermore, mRNA expression of MDA-7 is assessed in a cohort of
women with BC and correlated with established pathological parameters and clinical outcome. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
