Hfq affects mRNA levels independently of degradation |
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| Authors: | Jacques Le Derout Irina V Boni Philippe Régnier Eliane Hajnsdorf |
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| Affiliation: | 1.UPR CNRS n° 9073, conventionnée avec l'Université Paris 7 - Denis Diderot Institut de Biologie Physico-Chimique,France;2.Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences,Russia |
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| Abstract: | Background The bacterial Lsm protein, Hfq, is an RNA chaperone involved in many reactions related to RNA metabolism, such as replication and stability, control of small RNA activity and polyadenylation. Despite this wide spectrum of known functions, the global role of Hfq is almost certainly undervalued; its capacity to bind DNA and to interact with many other proteins are only now beginning to be taken into account. |
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