Soluble L1CAM promotes breast cancer cell adhesion and migration in vitro, but not invasion |
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| Authors: | Yupei Li Deni S Galileo |
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| Affiliation: | (1) Department of Biological Sciences, University of Delaware, Wolf Hall, 19716 Newark, DE, USA |
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| Abstract: | Background Neural recognition molecule L1CAM, which is a key protein involved in early nervous system development, is known to be abnormally expressed and shed in several types of cancers where it participates in metastasis and progression. The distinction of L1CAM presence in cancerous vs. normal tissues has suggested it to be a new target for cancer treatment. Our current study focused on the potential role of soluble L1CAM in breast cancer cell adhesion to extracellular matrix proteins, migration, and invasion. |
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