Lysophosphatidylcholine Reversibly Arrests Pore Expansion during Syncytium Formation Mediated by Diverse Viral Fusogens |
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| Authors: | Marta Ciechonska Roy Duncan |
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| Institution: | aDepartment of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, Canada;bDepartment of Biochemistry & Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada;cDepartment of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada |
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| Abstract: | Using lysophosphatidylcholine, a curvature-inducing lysolipid, we have isolated a reversible, “stalled pore” phenotype during syncytium formation induced by the p14 fusion-associated small transmembrane (FAST) protein and influenza virus hemagglutinin (HA) fusogens. This is the first evidence that lateral propagation of stable fusion pores leading to syncytiogenesis mediated by diverse viral fusogens is inhibited by promotion of positive membrane curvature in the outer leaflets of the lipid bilayer surrounding intercellular fusion pores. |
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