The Diabetic Nephropathy and the Development of Hypertension in Rats |
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| Authors: | Adriana Zuccollo Monica Navarro Orlando Catanzaro |
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| Institution: | 1. PROSIVAD-CONICET, Catedra de Animales de Laboratorio, Facultad de Farmacia y Bioquimica-UBA, Argentina.;2. PROSIVAD-CONICET, Instituto Universitario de Ciencias de la Salud, Facultad de Medicina-Fundacion, Barcelo, Argentina.;3. Universidad Del Salvador, Fac. de Medicina, Cat. de Fisiologia, Tucuman, Buenos Aires, 1845 CP 1050, Argentina, |
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| Abstract: | The present study was designed to examine the development
of hypertension in diabetic rats treated
with streptozotocin (STZ, 1mg/g bw). The rats were
studied at 3, 6, 9, 12 and 15 weeks. From the third
week the rats were divided in diabetic rats according
their glycemias and controls, along 15 weeks. After
the third week a group, of rats showed increased urinary
protein excretion (93, 134, 155 and 191%) compared
to controls. In this group of rats the urinary
kallikrein excretion was lower than control and the
systolic blood pressure became significantly elevated
between 3 and 6 weeks and persisted up to 15 weeks.
On the other hand a group of diabetic rats were normotensive
with urinary protein excretion similar to
controls and urinary kallikrein lower compared to
control but significantly higher compared diabetic
hypertensive rats. These data suggest that the association
of progressive diabetic nephropathy with abnormal
endothelium-dependent vasodilation may
produce a high prevalence of hypertensive diabetes. |
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