| 微生物转化技术在中药开发中的应用进展 |
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| 引用本文： | 关松磊,吴雅馨,孙赫,张亚超,赵容祺,王虹,孙立静,苏玲. 微生物转化技术在中药开发中的应用进展[J]. 微生物学通报, 2018, 45(4): 900-906 |
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| 作者姓名： | 关松磊 吴雅馨 孙赫 张亚超 赵容祺 王虹 孙立静 苏玲 |
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| 作者单位： | 1. 吉林农业大学生命科学学院 吉林 长春 130118,1. 吉林农业大学生命科学学院 吉林 长春 130118,1. 吉林农业大学生命科学学院 吉林 长春 130118,1. 吉林农业大学生命科学学院 吉林 长春 130118,1. 吉林农业大学生命科学学院 吉林 长春 130118,1. 吉林农业大学生命科学学院 吉林 长春 130118,1. 吉林农业大学生命科学学院 吉林 长春 130118,2. 吉林农业大学食药用菌教育部工程研究中心 吉林 长春 130118 |
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| 基金项目： | 吉林省大学生创新创业训练计划项目；吉林农业大学大学生科技创新基金 |
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| 摘 要： | 中药现代化是目前中药研究最迫切的需要,微生物转化技术可以利用微生物的特性解决中药现代化研究中难以解决的诸多问题,我们总结了微生物转化中药的特点,转化酶系统及反应类型,分析了微生物生物转化对中药的影响,认为微生物转化技术酶系统广泛,选择性强,反应条件温和可控,反应类型广泛,适用于所有类型的中药有效成分的生物转化,经过转化后,可以提高中药药效,降低毒性,去除杂质,帮助有效成分的体内代谢及产生新的药物成分。中药微生物转化技术必定成为中药学与微生物学完美契合的典范,推进中药现代化的进程。
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| 关 键 词： | 微生物，中药，生物转化，药效 |
Application of microbial transformation technology in the development of Chinese medicine |
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| GUAN Song-Lei,WU Ya-Xin,SUN-He,ZHANG Ya-Chao,ZHAO Rong-Qi,WANG Hong,SUN Li-Jing and SU Ling. Application of microbial transformation technology in the development of Chinese medicine[J]. Microbiology China, 2018, 45(4): 900-906 |
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| Authors: | GUAN Song-Lei WU Ya-Xin SUN-He ZHANG Ya-Chao ZHAO Rong-Qi WANG Hong SUN Li-Jing SU Ling |
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| Affiliation: | 1. College of Life Science, Jilin Agricultural University, Changchun, Jilin 130118, China,1. College of Life Science, Jilin Agricultural University, Changchun, Jilin 130118, China,1. College of Life Science, Jilin Agricultural University, Changchun, Jilin 130118, China,1. College of Life Science, Jilin Agricultural University, Changchun, Jilin 130118, China,1. College of Life Science, Jilin Agricultural University, Changchun, Jilin 130118, China,1. College of Life Science, Jilin Agricultural University, Changchun, Jilin 130118, China,1. College of Life Science, Jilin Agricultural University, Changchun, Jilin 130118, China and 2. Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun, Jilin 130118, China |
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| Abstract: | The modernization is the most urgent to traditional Chinese medicine research. Microbial biotransformation can help to solve many difficult problems of traditional Chinese medicine research. The article summarizes the characteristics of microbial biotransformation, enzyme systems and reaction types, and analyze the influence of Chinese medicine microbial biotransformation. The conclusions were that the enzyme systems had widely variability, strong selectivity, mild and controllable reaction conditions, multiple reaction types to all active ingredients of traditional Chinese medicine, and the technology was very suitable for the daily and industrial production. After biotransformation, the effects of drugs can be improved, reduce the toxicity, remove the impurities, help to the metabolism in vivo and produce new drug ingredients. The Chinese medicine combinated with microbiology model will significantly promote the modernization of traditional Chinese medicine process. |
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| Keywords: | Microorganism Traditional Chinese medicine Biotransformation Drug effect |
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