Brownian dynamics simulation of nucleosome formation and disruption under stretching |
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Authors: | Li Wei Dou Shuo-Xing Wang Peng-Ye |
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Affiliation: | Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080. |
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Abstract: | Using a Brownian dynamics simulation, we numerically studied the interaction of DNA with histone and proposed an octamer-rotation model to describe the process of nucleosome formation. Nucleosome disruption under stretching was also simulated. The theoretical curves of extension versus time as well as of force versus extension are consistent with previous experimental results. |
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Keywords: | DNA Histone Interaction Nucleosome formation Nucleosome disruption |
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