Selected indices of immunoreactivity dependent on HBV infection in patients with alcoholic liver cirrhosis]

The study involved 85 patients with alcohol-produced liver cirrhosis divided into two groups depending on the presence or absence of HBV infection serological markers (HBV+-51; HBV-34). The study was aimed at comparing selected indices of both humoral and cell-mediated reactions in the blood of patients with alcohol-produced liver cirrhosis depending on immuno-serologically confirmed infection with HBV. Statistically significant differences between both groups concerned percentage of OKT4 (HBV+-67.7%; HBV--58.4%), and complement component C4 (0.32 and 0.48 g/L, respectively). Moreover, a significant decrease in percentage of T-cell and significant increase in IgG, IgA, IgM, and immunological complexes levels were noted when comparing with normal values. Results indicate, that the immunopathological reactions resulting from action of the two most frequent, harmful, hepatotropic, factors, i.e. alcohol and HBV, are different.