Per-O-(3-hydroxy)propyl-beta-cyclodextrin: a cyclodextrin derivative bearing only primary hydroxyl groups |
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Authors: | Badi Nezha Guégan Philippe |
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Affiliation: | Laboratoire Matériaux Polymères aux Interfaces-LRP, UMR CNRS 7581, Université d'Evry Val d'Essonne, Evry, France. |
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Abstract: | Natural beta-cyclodextrin (cyclomaltoheptaose) was treated with sodium hydride and allyl bromide to form the per-O-allyl-beta-cyclodextrin. 9-BBN, sodium hydroxide and hydrogen peroxide were then added to form, after adequate treatments, the desired per-O-(3-hydroxy)propyl-beta-cyclodextrin in yields close to 65%. This modified cyclodextrin, which bears only primary hydroxyl groups, can be used as a macro-initiator of the anionic polymerisation of ethylene oxide to form star-shaped polymers. The presence of only primary hydroxyl groups allows us to expect identical initiation kinetics for all the hydroxyl groups of the modified glucopyranosyl units. |
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Keywords: | Cyclodextrin Per-(3-hydroxypropyl)-β-cyclodextrin Primary hydroxyl groups |
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