The Endosteum Region Keeps Human Leukemic Stem Cells Alive |
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| Authors: | Lapidot Tsvee Goichberg Polina Lapid Kfir Avigdor Abraham Kollet Orit |
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| Affiliation: | Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel. tsvee.lapidot@weizmann.ac.il |
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| Abstract: | Only a subset of hierarchically arranged, primitive human AML progenitor cells can initiate the disease in transplanted immune-deficient mice. A publication in Nature Biotechnology by Ishikawa et al. (2007) describes a new animal model to study chemotherapy-resistant, quiescent human AML CD34(+)CD38(-) stem cells, which are retained in the endosteum region. |
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